Description

Clindamycin Phosphate is a semi-synthetic lincosamide antibiotic, widely recognized for its potent activity against anaerobic bacteria and certain protozoa. This water-soluble phosphate ester derivative is a critical active pharmaceutical ingredient (API) essential for formulating effective anti-infective medications. It is primarily utilized by pharmaceutical manufacturers in the production of injectable solutions, topical gels, and lotions for treating serious bacterial infections.

Application

• Primary Active Pharmaceutical Ingredient (API) in injectable antibiotic formulations for systemic infections.
• Key component in topical dermatological products such as gels, creams, and lotions for acne vulgaris.
• Used in the manufacture of vaginal creams and suppositories for bacterial vaginosis.
• Essential raw material for ophthalmic solutions targeting ocular infections.
• Research and development of novel drug delivery systems and combination therapies.
• Reference standard in analytical laboratories for quality control and method validation.

Basic Information

Product Name	Clindamycin Phosphate
CAS No.	24729-96-2
Molecular Formula	C18H34ClN2O8PS
Molecular Weight	504.96 g/mol
Synonyms	Clindamycin 2-Phosphate; Clindamycin Dihydrogen Phosphate; 7(S)-Chloro-7-deoxylincomycin 2-phosphate; U-28508; Dalacin® Phosphate; Cleocin® Phosphate; (2S,4R)-N-[(1S,2S)-2-Chloro-1-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(methylsulfanyl)oxan-2-yl]propyl]-1-methyl-4-propylpyrrolidine-2-carboxamide; 2-dihydrogen phosphate
EINECS	246-435-1

Quality Control

Our Clindamycin Phosphate is manufactured under strict quality systems and can be supplied to meet USP, EP, BP, and JP pharmacopeial standards. Every batch undergoes comprehensive analytical testing, including HPLC for assay and related substances, residual solvent analysis, and microbiological examination. A Certificate of Analysis (COA) documenting full compliance with specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time corresponds to reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any individual impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
pH (1% solution)	3.5 - 5.0
Specific Rotation	+115° to +130°
Bacterial Endotoxins	< 0.5 EU/mg
Microbial Enumeration	Complies with EP/USP

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.