Description

Estradiol-3-Glucoside is a conjugated metabolite of the primary female sex hormone, estradiol, where a glucose molecule is attached at the 3-position. This chemical modification significantly alters its solubility, bioavailability, and metabolic pathway compared to the parent hormone. It serves as a critical reference standard and intermediate in pharmaceutical research and development, particularly in the study of estrogen metabolism and hormone replacement therapies. This high-purity compound is essential for analytical laboratories, research institutions, and pharmaceutical companies focused on endocrinology, biomarker discovery, and the synthesis of more complex steroid derivatives.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantitative and qualitative analysis of estrogen metabolites in biological samples via HPLC, LC-MS, or GC-MS.
• Biochemical Research: A vital tool for studying the glucuronidation pathways of estradiol, enzyme kinetics, and the role of conjugated estrogens in physiological and pathological processes.
• Diagnostic Kit Development: Employed in the calibration and validation of immunoassays and diagnostic kits designed to measure estrogen levels in clinical settings.
• Metabolite Synthesis: Acts as a key synthetic intermediate or precursor for the preparation of other labeled or modified steroid conjugates for advanced research.
• Toxicology & Drug Metabolism Studies: Utilized to investigate the metabolic fate, excretion profiles, and potential bioactivity of estrogenic compounds.

Basic Information

Product Name	Estradiol-3-Glucoside
CAS No.	24703-07-9
Molecular Formula	C24H32O7
Molecular Weight	432.51 g/mol
Synonyms	Estradiol 3-β-D-Glucopyranoside; 17β-Estradiol 3-glucoside; Estr-1,3,5(10)-triene-3,17β-diol 3-glucoside; 3-Glucosylestradiol; Estradiol 3-D-glucoside; Estradiol 3-monoglucoside; 17β-Estradiol 3-β-D-glucoside
EINECS	Contact for details

Quality Control

Our Estradiol-3-Glucoside is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including identification by spectroscopic methods (IR, NMR), purity assessment by HPLC, and determination of residual solvents and moisture content. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with your research or production standards. Specifications can be aligned with pharmacopeial guidelines (e.g., USP) for reference standard applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a low-humidity environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.