Description

2,2,3,3-D4-3-(Trimethylsilyl)Propionic Acid Sodium Salt is a deuterated and silylated derivative of propionic acid, specifically designed as an internal standard for Nuclear Magnetic Resonance (NMR) spectroscopy. Its core value lies in providing a chemically inert, non-interfering signal for precise quantitative and qualitative analysis in complex mixtures. This high-purity compound is essential for researchers and quality control laboratories in the pharmaceutical, agrochemical, and advanced materials sectors who require uncompromised accuracy in their spectroscopic data.

Application

• Primary use as a quantitative internal standard (QIS) in 1H, 13C, and 2H NMR spectroscopy for pharmaceutical impurity profiling and reaction monitoring.
• Critical component in metabolomics and metabolomic studies for the accurate quantification of biological samples.
• Essential reference material in polymer and material science research for analyzing molecular structure and dynamics.
• Used in the development and validation of analytical methods according to ICH Q2(R1) guidelines in regulatory environments.
• Application in deuterium labeling studies and kinetic isotope effect (KIE) investigations.
• Serves as a chemical shift reference in non-aqueous NMR solvents for organic chemistry applications.

Basic Information

Product Name	2,2,3,3-D4-3-(Trimethylsilyl)Propionic Acid Sodium Salt
CAS No.	24493-21-8
Molecular Formula	C6H9D4NaO2Si
Molecular Weight	164.28 g/mol
Synonyms	Sodium 3-(Trimethylsilyl)-2,2,3,3-d4-propionate; TSP-d4 Sodium Salt; DSS-d4 (Deuterated Sodium 3-(Trimethylsilyl)propionate); NMR Reference Standard d4-TMSP; 3-(Trimethylsilyl)-2,2,3,3-tetradeutero-propionic Acid Sodium Salt; Sodium 3-(Trimethylsilyl)propionate-2,2,3,3-d4; TMSP-d4 Na Salt; Deuterated Sodium Trimethylsilylpropionate
EINECS	Contact for details

Quality Control

Every batch of our 2,2,3,3-D4-3-(Trimethylsilyl)Propionic Acid Sodium Salt is manufactured and tested to meet the stringent requirements for NMR reference standards. We guarantee high isotopic purity (D-enrichment) and chemical purity as critical quality attributes. Comprehensive testing includes NMR assay, isotopic enrichment analysis, and impurity profiling. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring traceability and compliance with your internal quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Deuterium Enrichment (min)	98 atom % D
Purity (NMR Assay, min)	99.0%
Chemical Shift (1H NMR in D2O)	0.00 ppm
Water Content (KF)	< 1.0 %
Residual Solvents (GC)	Meets ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.