Description

7,8-Didehydro-4,5α-Epoxy-6α-Hydroxy-17-(2-Propenyl)Morphinan-3-Yl β-D-Glucopyranosiduronic Acid is a high-purity, specialized chemical reference standard and pharmaceutical intermediate of significant interest in advanced research and development. Its primary value lies in its role as a key metabolite and derivative for studying the pharmacokinetics, metabolism, and analytical detection of related morphinan compounds. This product is essential for organizations engaged in pharmaceutical R&D, forensic analysis, and the development of high-sensitivity analytical methods, where precise chemical standards are critical for method validation and regulatory compliance.

Application

• Pharmaceutical Reference Standard: Used as a certified standard for the quantitative and qualitative analysis (e.g., HPLC, LC-MS) of related active pharmaceutical ingredients (APIs) and their metabolites in drug development and quality control.
• Metabolite Research: Serves as a critical tool in pharmacokinetic and metabolic pathway studies to understand the biotransformation and clearance of parent morphinan drugs.
• Forensic Toxicology: Employed as a calibrant and control in forensic laboratories for the accurate identification and quantification of specific substances in biological samples.
• Analytical Method Development: Essential for developing, validating, and verifying sophisticated chromatographic and mass spectrometric methods in compliance with GLP and ICH guidelines.
• Biochemical Research: Used in studies investigating receptor binding, enzyme interactions, and other biochemical mechanisms related to morphinan derivatives.
• Impurity Profiling: Acts as a characterized impurity or degradation product standard for stability testing and impurity identification in pharmaceutical formulations.

Basic Information

Product Name	7,8-Didehydro-4,5α-Epoxy-6α-Hydroxy-17-(2-Propenyl)Morphinan-3-Yl β-D-Glucopyranosiduronic Acid
CAS No.	24459-59-4
Molecular Formula	C28H33NO9
Molecular Weight	527.56 g/mol
Synonyms	Naloxone 3-β-D-Glucuronide; Naloxone Glucuronide; 17-Allyl-4,5α-epoxy-3,14-dihydroxymorphinan-6-one 3-β-D-Glucuronide; Naloxone-3-Glucuronide; Naloxone 3-Glucuronide; Naloxone β-D-Glucuronide; 3-Glucuronide of Naloxone; 17-Allyl-4,5α-epoxy-3,14-dihydroxymorphinan-6-one 3-glucuronide
EINECS	Contact for details

Quality Control

Our 7,8-Didehydro-4,5α-Epoxy-6α-Hydroxy-17-(2-Propenyl)Morphinan-3-Yl β-D-Glucopyranosiduronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity confirmation and structural verification by spectroscopic methods (NMR, MS), to ensure it meets the high standards required for research and reference materials. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation. The material should be handled in a controlled environment to ensure integrity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum consistent with structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Specific Optical Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.