Description

2-(3,4-Dihydroxy-Benzylidene)-Benzofuran-3-One, Sphingosine Kinase Inhibitor V is a potent and selective small-molecule inhibitor of sphingosine kinase, a key enzyme in the sphingolipid signaling pathway. This compound is a critical research tool for investigating the role of sphingosine-1-phosphate (S1P) in cellular processes such as proliferation, survival, and migration. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in oncology, immunology, and inflammatory disease research. The product is supplied with a Certificate of Analysis to ensure research-grade quality and batch-to-batch consistency.

Application

• Biomedical Research: A key pharmacological tool for studying the sphingolipid metabolic pathway and its implications in cell signaling.
• Oncology Research: Used to investigate the role of sphingosine kinase in cancer cell growth, survival, and metastasis, supporting the development of novel anti-cancer therapies.
• Immunology & Inflammation Studies: Applied in research models to understand and modulate S1P-mediated immune cell trafficking and inflammatory responses.
• Drug Discovery & Development: Serves as a reference standard and lead compound in high-throughput screening and structure-activity relationship (SAR) studies for sphingosine kinase targets.
• Academic & Institutional Research: Essential for basic scientific research in biochemistry, molecular biology, and pharmacology departments worldwide.
• Preclinical Studies: Utilized in animal models to validate sphingosine kinase as a therapeutic target and to assess the efficacy of intervention strategies.

Basic Information

Product Name	2-(3,4-Dihydroxy-Benzylidene)-Benzofuran-3-One, Sphingosine Kinase Inhibitor V
CAS No.	24418-86-8
Molecular Formula	C15H10O5
Molecular Weight	270.24 g/mol
Synonyms	SKI-V; Sphingosine Kinase Inhibitor V; 2-[(3,4-Dihydroxyphenyl)methylene]-3(2H)-benzofuranone; (Z)-2-(3,4-Dihydroxybenzylidene)benzofuran-3(2H)-one; 2-(3,4-Dihydroxybenzylidene)-3-benzofuranone; NSC 35446; Benzofuran-3-one, 2-(3,4-dihydroxybenzylidene)-
EINECS	Contact for details

Quality Control

Our 2-(3,4-Dihydroxy-Benzylidene)-Benzofuran-3-One is manufactured under strict quality control protocols to ensure high purity and reliability for research applications. Each batch is analyzed using advanced techniques including HPLC, NMR, and mass spectrometry to confirm identity and potency. A comprehensive Certificate of Analysis (COA) detailing purity, assay results, and impurity profiles is provided with every shipment to support your research documentation and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. For short-term use, the product may be stored at 2-8°C. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation. This compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.