Description

Doxorubicinone CAS NO 24385-10-2 is the key aglycone intermediate in the synthesis of the potent anthracycline antibiotic doxorubicin. This compound is of critical importance for pharmaceutical research and development, serving as the core structural scaffold for a class of vital chemotherapeutic agents. It is primarily required by fine chemical manufacturers, pharmaceutical R&D laboratories, and academic institutions focused on oncology drug discovery and the development of novel anthracycline derivatives.

Application

• Pharmaceutical Intermediate: Primary use as the essential aglycone precursor in the chemical synthesis of Doxorubicin (Adriamycin) and related anthracycline chemotherapeutics.
• Oncology Research: Core scaffold for the design, synthesis, and structure-activity relationship (SAR) studies of new anti-cancer agents targeting DNA intercalation and topoisomerase II inhibition.
• Reference Standard: Serves as a high-purity chemical reference standard (CRS) for analytical method development, validation, and quality control in pharmaceutical manufacturing.
• Biochemical Studies: Used in research to investigate the mechanism of action, metabolism, and resistance pathways of anthracycline drugs.
• Conjugate Development: Foundation molecule for developing advanced drug conjugates, such as antibody-drug conjugates (ADCs) and nanoparticle formulations, to improve therapeutic index.

Basic Information

Product Name	Doxorubicinone
CAS No.	24385-10-2
Molecular Formula	C21H18O9
Molecular Weight	414.36 g/mol
Synonyms	Doxorubicin Aglycone; (7S,9S)-7-[(2R,4S,5S,6S)-4-Amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione; 7-Deoxyadriamycinone; Adriamycinone; 14-Hydroxydaunomycinone; 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-; Doxorubicinone Hydrochloride (salt form)
EINECS	Contact for details

Quality Control

Our Doxorubicinone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and assay, identification by spectroscopic methods (IR, NMR), and control of related substances and residual solvents. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with research and pharmaceutical intermediate standards.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) or as specified on the label or COA. This product is light-sensitive and easily oxidized; prolonged exposure to air, light, or moisture should be avoided to maintain stability and potency.

Specification

Item	Specification
Appearance	Orange to red powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.