Description

Methyllycaconitine CAS NO 24342-56-1 is a potent, naturally occurring norditerpenoid alkaloid isolated from plants of the *Delphinium* genus. This compound serves as a highly selective and competitive antagonist for the α7 subtype of nicotinic acetylcholine receptors (nAChRs), making it a critical research tool in neuropharmacology. It is primarily utilized by researchers and developers in the pharmaceutical, biotechnology, and agrochemical sectors for receptor characterization, neurological disorder studies, and the development of novel therapeutic agents.

Application

• Neuroscience Research: A key pharmacological tool for selectively blocking α7 nAChRs in studies of synaptic transmission, cognitive function, and neuroinflammation.
• Drug Discovery & Development: Used in high-throughput screening and target validation for conditions like schizophrenia, Alzheimer's disease, and inflammatory pain where α7 receptors are implicated.
• Biochemical Assays: Employed as a reference standard in competitive binding assays (e.g., with [³H]MLA) to determine receptor affinity and density.
• Toxicology Studies: Investigated for its role in plant-based toxicology and as a model compound for studying the effects of norditerpenoid alkaloids.
• Academic & Institutional Research: Essential for basic research in university and government laboratories focusing on cholinergic signaling pathways.

Basic Information

Product Name	Methyllycaconitine
CAS No.	24342-56-1
Molecular Formula	C37H50N2O10
Molecular Weight	682.80 g/mol
Synonyms	MLA; Methyllycaconitine citrate; Lycoctonine, 14,16-didehydro-20-methyl-1,6,8,14-tetrahydro-, (1α,6β,14α,16β)-; 16β-Methyllycaconitine; O,O-Diacetyldelectine; NSC 338711; Delphinium alkaloid MLA
EINECS	Contact for details

Quality Control

Our Methyllycaconitine is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity verification and structural confirmation via spectroscopic methods. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. The product is light-sensitive (store away from light). Allow the container to reach room temperature before opening to minimize moisture condensation. Keep under inert atmosphere if specified for the specific grade.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95% (Research Grade)
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.