Description

2,3,5,6-Tetrafluoro-4-Hydroxybenzaldehyde is a highly functionalized aromatic aldehyde characterized by its unique tetrafluoro substitution pattern. This compound serves as a critical advanced pharmaceutical intermediate (API) and a versatile building block for synthesizing complex molecules. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries to introduce fluorinated aromatic motifs, which are essential for modulating the biological activity and physicochemical properties of target compounds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of fluorinated active pharmaceutical ingredients (APIs), particularly for drugs targeting the central nervous system, oncology, and anti-infective therapies.
• Agrochemical Synthesis: Used to create novel fluorinated herbicides, fungicides, and pesticides, where the fluorine atoms enhance bioavailability and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated components in electronic display materials, improving their dielectric anisotropy and thermal stability.
• Polymer & Resin Modifier: Incorporated into specialty polymers to impart unique properties such as chemical resistance, low surface energy, and enhanced weatherability.
• Organic Synthesis Reagent: Employed in cross-coupling reactions, Schiff base formation, and as a directing group in metal-catalyzed transformations for complex molecule assembly.
• Fluorinated Dye & Pigment Precursor: Used in the development of high-performance, light-fast colorants for advanced imaging and coating applications.

Basic Information

Product Name	2,3,5,6-Tetrafluoro-4-Hydroxybenzaldehyde
CAS No.	24336-73-0
Molecular Formula	C7H2F4O2
Molecular Weight	194.08 g/mol
Synonyms	4-Hydroxy-2,3,5,6-tetrafluorobenzaldehyde; 2,3,5,6-Tetrafluoro-4-hydroxybenzenecarboxaldehyde; Tetrafluorohydroxybenzaldehyde; Perfluorohydroxybenzaldehyde; 4-Formyl-2,3,5,6-tetrafluorophenol; 2,3,5,6-Tetrafluoro-4-hydroxy-benzaldehyde; 2,3,5,6-Tetrafluoro-4-hydroxybenzaldehyde (Tetrafluorosalicylaldehyde derivative)
EINECS	Contact for details

Quality Control

Our 2,3,5,6-Tetrafluoro-4-Hydroxybenzaldehyde is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure high purity and batch-to-batch consistency. We provide comprehensive Certificates of Analysis (COA) with all shipments, detailing identity, purity, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, supporting its use in regulated synthesis pathways.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from strong oxidizing agents, strong bases, and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	142 - 147 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.