Description

5-Chloro-2-Iodobenzotrifluoride is a versatile halogenated aromatic building block of significant importance in advanced organic synthesis. Its unique structure, featuring chlorine, iodine, and a trifluoromethyl group on a benzene ring, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought by research and development chemists in the pharmaceutical and agrochemical industries for applications in cross-coupling reactions and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds requiring halogenated aromatic scaffolds.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science Research: Serves as a building block for creating specialty polymers, liquid crystals, and organic electronic materials due to its distinct electronic properties.
• Cross-Coupling Reactions: The iodine atom is an excellent site for palladium-catalyzed reactions like Suzuki, Sonogashira, and Heck couplings, enabling rapid diversification of molecular structures.
• Ligand and Catalyst Development: Employed in the synthesis of specialized ligands for catalysis and molecular recognition studies.
• Chemical Research & Development: A valuable reagent for academic and industrial R&D labs exploring new synthetic methodologies and fluorine chemistry.

Basic Information

Product Name	5-Chloro-2-Iodobenzotrifluoride
CAS No.	23399-77-1
Molecular Formula	C7H3ClF3I
Molecular Weight	305.45 g/mol
Synonyms	2-Iodo-5-chlorobenzotrifluoride; 1-Chloro-4-iodo-2-(trifluoromethyl)benzene; 5-Chloro-α,α,α-trifluoro-2-iodotoluene; 2-Iodo-5-chloro-α,α,α-trifluorotoluene; Benzene, 1-chloro-4-iodo-2-(trifluoromethyl)-; 5-Chloro-2-iodobenzyl trifluoride
EINECS	Contact for details

Quality Control

Our 5-Chloro-2-Iodobenzotrifluoride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for demanding synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality management system is designed to meet the rigorous standards required by research and fine chemical industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging during storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.