Description

Histamine Diphosphate is a high-purity, stable salt form of the biogenic amine histamine, widely used in research and diagnostic applications. This compound is critical for its role as a precise biochemical tool in pharmacological studies and immunoassay development. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and clinical diagnostics sectors who require a reliable and well-characterized reference standard.

Application

• Pharmacological Research: Used as a key reference standard and agonist in studies of histamine receptors (H1, H2, H3, H4) to investigate allergic responses, gastric acid secretion, and neurological functions.
• Immunoassay Development: Serves as a critical hapten for the production of antibodies and the calibration of ELISA and other immunoassay kits for histamine detection.
• Diagnostic Reagents: A fundamental component in the formulation of in-vitro diagnostic (IVD) reagents for quantifying histamine levels in clinical and research samples.
• Biochemical Reference Standard: Provides a certified reference material for quality control and method validation in analytical laboratories to ensure accurate measurement of histamine.
• Cell Culture & Physiology Studies: Employed in experimental models to simulate histaminergic responses and study intracellular signaling pathways.

Basic Information

Product Name	Histamine Diphosphate
CAS No.	23297-93-0
Molecular Formula	C5H9N3 · 2H3PO4
Molecular Weight	307.14 g/mol
Synonyms	Histamine Acid Phosphate; Histamine Phosphate; Histamine Dihydrogen Phosphate; 2-(1H-Imidazol-4-yl)ethanamine Diphosphate; 4-(2-Aminoethyl)imidazole Diphosphate; Ergamine Diphosphate; 1H-Imidazole-4-ethanamine, phosphate (1:2)
EINECS	245-563-7

Quality Control

Our Histamine Diphosphate is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including identification, purity assay, and impurity profiling, to ensure it meets stringent specifications for research and diagnostic use. Certificates of Analysis (COA) with detailed HPLC/UV data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	White or almost white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (Titration)	Conforms
Assay (HPLC)	≥ 98.0% (on anhydrous basis)
Water (Karl Fischer)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
pH (5% solution)	2.5 - 3.5
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.