Description

Dimaprit Dihydrochloride is a selective histamine H2-receptor agonist, a crucial research tool for pharmacological studies. Its primary value lies in its ability to selectively stimulate H2 receptors, making it indispensable for investigating gastric acid secretion, cardiovascular function, and immune modulation. This compound is essential for pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on receptor pharmacology and drug discovery.

Application

• Pharmacological Research: A standard agonist for studying histamine H2 receptor function, signaling pathways, and receptor characterization in vitro and in vivo.
• Gastric Secretion Studies: Used to model and investigate the mechanisms of gastric acid secretion and to evaluate potential anti-ulcer therapeutics.
• Cardiovascular Research: Employed to explore the role of H2 receptors in heart rate modulation and vascular responses.
• Immunology and Inflammation Research: Applied in studies examining the modulation of cytokine release and immune cell activity mediated by H2 receptors.
• Neuroscience: Utilized in central nervous system research to understand the neuromodulatory effects of histamine via H2 receptors.
• Drug Discovery & Screening: Serves as a reference compound and positive control in high-throughput screening assays for identifying novel H2 receptor antagonists or agonists.
• Biochemical Assay Development: Acts as a key reagent in developing and validating functional cell-based assays for H2 receptor activity.

Basic Information

Product Name	Dimaprit Dihydrochloride
CAS No.	23256-33-9
Molecular Formula	C7H14N4S • 2HCl
Molecular Weight	279.65 g/mol
Synonyms	Dimaprit HCl; SK&F 91488; N-[3-(Dimethylamino)propyl]-N'-methyl-2-thiourea Dihydrochloride; 1-[3-(Dimethylamino)propyl]-3-methyl-2-thiourea Dihydrochloride; S-[3-(Dimethylamino)propyl]isothiourea Dihydrochloride; N-Methyl-N'-[3-(dimethylamino)propyl]thiourea Dihydrochloride; Histamine H2 Receptor Agonist
EINECS	Contact for details

Quality Control

Our Dimaprit Dihydrochloride is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation (IR, NMR), and residual solvent analysis, to ensure it meets the high standards required for critical research applications. A detailed Certificate of Analysis (COA) is provided with each shipment, guaranteeing traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.