Description

(1S,2S)-Bupropion n-1'-Deoxy-β-D-Glucuronic Acid is a high-purity, stereochemically defined metabolite and reference standard of the antidepressant bupropion. This compound is critical for pharmaceutical research and development, providing an essential tool for pharmacokinetic studies, metabolic pathway elucidation, and analytical method validation. It is primarily utilized by pharmaceutical companies, contract research organizations (CROs), and analytical laboratories focused on neuropharmacology and drug metabolism.

Application

• Pharmaceutical Reference Standard: Serves as a certified standard for the quantitative and qualitative analysis of bupropion and its metabolites in biological matrices and finished drug products.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used to investigate the metabolic fate, clearance pathways, and bioavailability of bupropion in preclinical and clinical research.
• Analytical Method Development: Essential for developing and validating precise HPLC, LC-MS, and GC-MS methods for impurity profiling and assay determination.
• Bioequivalence Testing: Employed as a critical comparator in studies for generic drug development to ensure therapeutic equivalence.
• Pharmacology Research: Supports studies on the mechanism of action, receptor binding, and stereospecific activity of bupropion and related compounds.
• Quality Control in Manufacturing: Used in-house by API manufacturers to monitor synthesis processes and ensure batch-to-batch consistency and purity.

Basic Information

Product Name	(1S,2S)-Bupropion n-1'-Deoxy-β-D-Glucuronic Acid
CAS No.	23018-83-9
Molecular Formula	C20H27NO8
Molecular Weight	409.43 g/mol
Synonyms	(1S,2S)-Hydroxybupropion Glucuronide; (1S,2S)-Bupropion Glucuronide; (2S,3S)-Hydroxybupropion β-D-Glucuronide; BW 306U Glucuronide; (1S,2S)-2-(3-Chlorophenyl)-2-hydroxy-3,5,5-trimethylmorpholin-4-ium-4-yl β-D-Glucopyranosiduronic Acid; (1S,2S)-Bupropion O-β-D-Glucuronide; Threo-Hydroxybupropion Glucuronide
EINECS	Contact for details

Quality Control

Our (1S,2S)-Bupropion n-1'-Deoxy-β-D-Glucuronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure compliance with high-grade reference standard specifications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% (1S,2S) isomer
Water Content (KF)	≤2.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.