Description

n-Acetylpuromycin is a chemically modified derivative of the classic protein synthesis inhibitor puromycin. This compound is a critical intermediate and research tool in the fields of biochemistry and molecular biology, valued for its role in studying ribosome function and translational mechanisms. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies engaged in the development of novel antibiotics and the study of gene expression.

Application

• Biochemical Research: As a key intermediate in the synthesis of puromycin analogs for studying protein synthesis inhibition.
• Antibiotic Mechanism Studies: Used to investigate the mode of action of aminonucleoside antibiotics on bacterial and eukaryotic ribosomes.
• Molecular Probe Development: Serves as a precursor for creating labeled probes to track translational activity in cellular assays.
• Pharmaceutical R&D: Employed in the discovery and development stages of new antimicrobial agents targeting protein synthesis.
• Cell Biology: Used in puromycin-associated techniques, such as the puromycin incorporation assay, to measure nascent protein synthesis.

Basic Information

Item	Detail
Product Name	n-Acetylpuromycin
CAS No.	22852-13-7
Molecular Formula	C23H30N7O6
Molecular Weight	500.53 g/mol
Synonyms	N-Acetylpuromycin; Puromycin, N-acetyl-; O-Methyl-L-tyrosyl-N-acetyl-3'-deoxy-3'-aminoadenosine; 3'-Deoxy-N6,N6-dimethyl-N-acetyl-3'-(O-methyl-L-tyrosylamino)adenosine; Acetylpuromycin; 3'-(4-Methoxy-L- phenylalanyl)-N-acetyl-3'-deoxy-N6,N6-dimethyladenosine
EINECS	Contact for details

Quality Control

Our n-Acetylpuromycin is produced under stringent quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.