Description

Ethyl 5-Fluoronicotinate is a high-purity fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. This compound is valued for its role in introducing the 5-fluoronicotinate moiety, which is essential for modulating the biological activity and physicochemical properties of target molecules. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of potential drug candidates, particularly in kinase inhibitor and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the preparation of advanced herbicides and pesticides where the fluoronicotinate structure contributes to efficacy and environmental profile.
• Ligand and Catalyst Development: Employed in the synthesis of specialized ligands for metal-organic frameworks (MOFs) or asymmetric catalysis.
• Material Science Research: Acts as a precursor for fluorinated organic electronic materials or liquid crystals.
• Chemical Biology Probes: Utilized to create labeled compounds or probes for studying biochemical pathways.
• Custom Synthesis and Contract Manufacturing: Supplied for bespoke synthesis projects requiring high-purity, specialized fluorinated intermediates.

Basic Information

Product Name	Ethyl 5-Fluoronicotinate
CAS No.	22620-29-7
Molecular Formula	C8H8FNO2
Molecular Weight	169.15 g/mol
Synonyms	5-Fluoronicotinic Acid Ethyl Ester; Ethyl 5-Fluoropyridine-3-carboxylate; 3-Pyridinecarboxylic Acid, 5-Fluoro-, Ethyl Ester; 5-Fluoro-3-pyridinecarboxylic Acid Ethyl Ester; 5-Fluoronictonic Acid Ethyl Ester; Ethyl 5-Fluoro-3-pyridinecarboxylate; 22620-29-7; 5-Fluoronicotinate ethyl ester
EINECS	Contact for details

Quality Control

Our Ethyl 5-Fluoronicotinate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with every shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical synthesis steps.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. The container should be kept tightly sealed in a dry environment to minimize moisture exposure.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.