Description

2-Fluoro-4-Iodopyridine is a versatile halogenated pyridine derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring both fluorine and iodine substituents, makes it a valuable precursor for constructing complex molecules via cross-coupling reactions. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for fluorinated drug candidates targeting CNS disorders and oncology.
• Agrochemical Synthesis: Building block for novel herbicides, fungicides, and insecticides, leveraging the bioactivity of fluorinated heterocycles.
• Material Science Research: Used in the development of organic electronic materials, liquid crystals, and metal-organic frameworks (MOFs).
• Cross-Coupling Reactions: Essential substrate for Suzuki, Stille, and Negishi couplings to introduce the pyridine moiety into complex molecular architectures.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing specialized ligands used in homogeneous catalysis.
• Chemical Biology Probes: Utilized in creating labeled compounds and probes for studying biological mechanisms and diagnostics.

Basic Information

Product Name	2-Fluoro-4-Iodopyridine
CAS No.	22282-70-8
Molecular Formula	C5H3F1I1N1
Molecular Weight	222.99 g/mol
Synonyms	4-Iodo-2-fluoropyridine; 2-Fluoro-4-iodopyridine; 4-Iodo-2-fluoro-pyridine; Pyridine, 2-fluoro-4-iodo-; 2-Fluoropyridin-4-yl iodide; FIP; 2-F-4-I-Pyridine
EINECS	Contact for details

Quality Control

Our 2-Fluoro-4-Iodopyridine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) for each lot, detailing purity, identity, and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive and should be stored away from light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.