Description

2-Fluoro-4-Hydroxypyridine is a versatile fluorinated pyridine derivative, a key heterocyclic building block prized for its unique electronic and steric properties. This compound is essential for introducing both fluorine and hydroxyl functional groups into complex molecular architectures, enabling fine-tuning of biological activity and material characteristics. It is primarily sought after by research chemists and process development teams in the pharmaceutical, agrochemical, and advanced materials sectors for the synthesis of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A crucial synthon for the development of active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine atom enhances bioavailability and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis for asymmetric synthesis.
• Material Science Research: Employed in the synthesis of fluorinated organic semiconductors, liquid crystals, and polymers with tailored electronic and optical properties.
• Chemical Biology Probes: Utilized as a building block for fluorinated analogs of biomolecules, aiding in metabolic pathway studies and protein-ligand interaction mapping.
• Custom Synthesis and Contract Manufacturing: A key starting material for custom synthesis projects and scale-up processes under cGMP or ISO standards.

Basic Information

Product Name	2-Fluoro-4-Hydroxypyridine
CAS No.	22282-69-5
Molecular Formula	C5H4FNO
Molecular Weight	113.09 g/mol
Synonyms	4-Hydroxy-2-fluoropyridine; 2-Fluoro-4-pyridinol; 2-Fluoropyridin-4-ol; 4-Pyridinol, 2-fluoro-; 2-Fluoro-4(1H)-pyridinone (tautomer); 2-Fluoro-4-hydroxypyridine; 2-F-4-OH-Py
EINECS	Contact for details

Quality Control

We maintain a rigorous quality management system to ensure batch-to-batch consistency and high purity. Our standard grade for 2-Fluoro-4-Hydroxypyridine typically meets a purity specification of ≥97% (by HPLC), with identity confirmed by IR and NMR spectroscopy. Certificates of Analysis (COA) detailing purity, impurities, and physical characteristics are provided with each shipment. We can support development and production under various quality frameworks, including ISO 9001 and ICH Q7 guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.