Description

3,5-Dichloro-2-Hydroxybenzenesulfonyl Fluoride is a specialized organosulfur and organofluorine compound that serves as a versatile building block in advanced chemical synthesis. Its unique structure, featuring both a sulfonyl fluoride and phenolic hydroxyl group, makes it a critical intermediate for constructing complex molecules with high precision. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of sulfonamide-based drugs, enzyme inhibitors, and targeted covalent inhibitors.
• Agrochemical Synthesis: Precursor for novel herbicides, fungicides, and plant growth regulators that require the sulfonyl fluoride moiety for bioactivity.
• Chemical Biology & Proteomics: Used as a reactive probe in activity-based protein profiling (ABPP) to label and study enzymes, particularly serine hydrolases.
• Material Science: Intermediate in the production of specialty polymers, liquid crystals, and advanced organic electronic materials.
• Cross-coupling Reactions: Serves as an electrophilic coupling partner in Suzuki-Miyaura and other palladium-catalyzed cross-coupling reactions to introduce the benzenesulfonyl group.
• Fluorination Reagent: Source of the sulfonyl fluoride functional group for introducing fluorine atoms into complex molecular architectures.

Basic Information

Product Name	3,5-Dichloro-2-Hydroxybenzenesulfonyl Fluoride
CAS No.	22243-89-6
Molecular Formula	C6H3Cl2FO3S
Molecular Weight	244.05 g/mol
Synonyms	2-Hydroxy-3,5-dichlorobenzenesulfonyl Fluoride; 3,5-Dichloro-2-hydroxybenzenesulfonic Acid Fluoride; 3,5-Dichlorosalicylic Acid Sulfonyl Fluoride; 2,6-Dichloro-3-fluorosulfonylphenol; Benzenesulfonyl fluoride, 3,5-dichloro-2-hydroxy-; 3,5-Dichloro-2-hydroxybenzene-1-sulfonyl fluoride
EINECS	Contact for details

Quality Control

Our production of 3,5-Dichloro-2-Hydroxybenzenesulfonyl Fluoride adheres to stringent quality management protocols. Every batch is analyzed using advanced chromatographic and spectroscopic techniques to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your quality assurance and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.