Description

Cytochalasin D CAS NO 22144-77-0 is a potent, cell-permeable fungal metabolite that acts as a specific inhibitor of actin polymerization. This compound is a critical research tool in cell biology for disrupting the actin cytoskeleton, enabling studies on cell motility, morphology, and intracellular transport. It is essential for researchers and manufacturers in the fields of life sciences, pharmaceutical development, and biochemical research.

Application

• Cytoskeleton Research: Used to study actin filament dynamics, cell division (cytokinesis), and cell shape changes by inhibiting microfilament formation.
• Cell Biology Studies: A key reagent for investigating processes like phagocytosis, vesicle trafficking, and membrane ruffling that depend on actin.
• Cancer Research: Employed to examine the role of the actin cytoskeleton in tumor cell invasion, metastasis, and drug resistance mechanisms.
• Neuroscience: Utilized in studies of neuronal growth cone dynamics and synaptic plasticity where actin remodeling is crucial.
• Developmental Biology: Applied to understand actin's function in embryogenesis and tissue morphogenesis.
• Pharmaceutical Screening: Serves as a reference compound or positive control in high-throughput assays targeting the cytoskeleton.

Basic Information

Product Name	Cytochalasin D
CAS No.	22144-77-0
Molecular Formula	C30H37NO6
Molecular Weight	507.62 g/mol
Synonyms	Zygosporin A; Cytochalasin D from Zygosporium masonii; [S-(R*,S*)]-N-[(1,5,6,7-Tetrahydro-2-hydroxy-1,7-dioxo-4H-isoindol-4-yl)carbonyl]-L-phenylalanyl-2-methyl-D-tryptophan 6-lactone; Phomin; NSC 209835; 7-Oxadehydrophomin; 22,23-Dihydro-7-oxadehydrophomin
EINECS	244-798-6

Quality Control

Our Cytochalasin D is produced under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Solubility	Soluble in DMSO, DMF; sparingly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.