Description

5-Chloro-2-Nitrobenzenesulfonyl Chloride is a versatile and highly reactive sulfonyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its primary value lies in its ability to act as a sulfonylation reagent, facilitating the introduction of the sulfonyl functional group to create complex molecules with specific properties. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who require high-purity intermediates for the development of active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of sulfonamide-based drug candidates, including enzyme inhibitors and receptor antagonists.
• Agrochemical Synthesis: Used in the manufacture of herbicides, fungicides, and pesticides where the sulfonyl moiety impributes biological activity.
• Dyestuff and Pigment Production: Acts as an intermediate for creating sulfonated azo dyes and other colorants with enhanced solubility and fastness properties.
• Polymer Chemistry: Employed in the synthesis of specialty polymers and resins, such as sulfonated polymers for ion-exchange membranes.
• Chemical Research & Development: A valuable reagent for exploring new sulfonylation reactions and constructing molecular libraries for screening.
• Ligand and Catalyst Preparation: Used to synthesize sulfonamide ligands for metal complexes in catalytic applications.

Basic Information

Product Name	5-Chloro-2-Nitrobenzenesulfonyl Chloride
CAS No.	21792-87-0
Molecular Formula	C6H3Cl2NO4S
Molecular Weight	256.06 g/mol
Synonyms	2-Nitro-5-chlorobenzenesulfonyl chloride; 5-Chloro-2-nitrobenzenesulfonyl chloride; 2-Nitro-5-chlorophenylsulfonyl chloride; Benzenesulfonyl chloride, 5-chloro-2-nitro-; 5-Chloro-2-nitrobenzene-1-sulfonyl chloride; NSC 403107; 1-Chloro-4-nitro-3-sulfonylchloride-benzene (alternative numbering)
EINECS	244-577-5

Quality Control

Every batch of 5-Chloro-2-Nitrobenzenesulfonyl Chloride is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We ensure compliance with stringent in-house specifications developed for high-purity synthetic intermediates. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat, open flames, and incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	68°C - 72°C
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.