Description

L-Methionine [S]-Sulfoximine is a potent and selective inhibitor of glutamine synthetase, a key enzyme in nitrogen metabolism. This compound is a critical research tool for studying cellular glutamine dependence, metabolic pathways, and related disease mechanisms. It is primarily utilized by researchers and developers in the pharmaceutical, biotechnology, and life sciences sectors for drug discovery and biochemical research.

Application

• Biochemical Research: A fundamental tool for investigating glutamine metabolism, ammonia detoxification, and nitrogen cycling in cell culture and enzymatic studies.
• Oncology Research: Used to study cancer cell metabolism, particularly the role of glutaminolysis in tumor growth and survival, supporting the development of novel therapeutic strategies.
• Neuroscience Studies: Applied in research models to explore the role of glutamine synthetase in astrocyte function, neurotransmitter recycling, and neurological disorders.
• Plant Biology & Agriculture: Serves as a probe to understand nitrogen assimilation and amino acid biosynthesis pathways in plants.
• Pharmaceutical Development: Acts as a reference standard and a starting point for the design and screening of new enzyme inhibitors targeting metabolic diseases.

Basic Information

Product Name	L-Methionine [S]-Sulfoximine
CAS No.	21752-32-9
Molecular Formula	C5H12N2O3S
Molecular Weight	180.23 g/mol
Synonyms	L-Methionine Sulfoximine; Methionine Sulfoximine; L-MSO; MSX; (S)-2-Amino-4-(methylsulfonimidoyl)butanoic acid; L-Methionine S,S-Dioxide Imine; NSC 113689; Glutamine Synthetase Inhibitor
EINECS	Contact for details

Quality Control

Our L-Methionine [S]-Sulfoximine is produced and tested under a strict quality management system to ensure batch-to-batch consistency and reliability for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We ensure compliance with relevant standards for research-grade biochemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation	[α]20/D: Specific range available on COA
Water Content (KF)	≤ 1.0%
Heavy Metals	< 20 ppm
Residue on Ignition	< 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.