Description

2-(Trifluoromethyl)Benzyl Chloride is a versatile and reactive organofluorine building block, essential for introducing the trifluoromethylbenzyl moiety into complex molecular architectures. This compound matters for its role in modulating the physicochemical properties of target molecules, enhancing lipophilicity and metabolic stability, which is critical in advanced material and pharmaceutical synthesis. It is primarily needed by R&D chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediates: Key synthon for the preparation of active pharmaceutical ingredients (APIs), particularly in the development of CNS agents and anti-inflammatory drugs.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and pesticides where the trifluoromethyl group improves biological activity.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorine-containing compounds used in electronic display technologies.
• Polymer Modification: Employed to introduce fluorinated side chains into polymers, altering surface properties and chemical resistance.
• Cross-Coupling Reactions: A valuable electrophile in Pd-catalyzed cross-coupling reactions (e.g., Suzuki, Negishi) for C-C bond formation.
• Ligand & Catalyst Development: Building block for synthesizing novel ligands and organocatalysts used in asymmetric synthesis.

Basic Information

Product Name	2-(Trifluoromethyl)Benzyl Chloride
CAS No.	21742-00-7
Molecular Formula	C8H6ClF3
Molecular Weight	194.58 g/mol
Synonyms	α-(Chloromethyl)-2-(trifluoromethyl)benzene; 2-(Trifluoromethyl)benzyl chloride; 1-(Chloromethyl)-2-(trifluoromethyl)benzene; o-(Trifluoromethyl)benzyl chloride; (2-Trifluoromethylphenyl)methyl chloride; 2-Trifluoromethylbenzylchloride; Benzene, 1-(chloromethyl)-2-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 2-(Trifluoromethyl)Benzyl Chloride is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request. We adhere to cGMP principles where applicable to support our customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.