Description

7,8-Dihydroxychlorpromazine is a key metabolite and derivative of the phenothiazine-class antipsychotic agent, chlorpromazine. This compound is of significant interest in pharmaceutical research and development, particularly for studying metabolic pathways and pharmacological activity. It serves as a critical reference standard and intermediate for analytical and synthetic applications in the life sciences. Industries requiring high-purity biochemicals for research, method validation, and advanced synthesis will find this product essential.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantification and identification of chlorpromazine metabolites in pharmacokinetic and bioanalytical studies.
• Biochemical Research: Employed in neuroscience and pharmacology research to investigate the metabolism, mechanism of action, and potential neurotoxic or antioxidant effects of phenothiazine derivatives.
• Analytical Chemistry: Serves as a critical calibration standard in high-performance liquid chromatography (HPLC), liquid chromatography-mass spectrometry (LC-MS), and other analytical techniques for method development and validation.
• Organic Synthesis Intermediate: Utilized as a building block for the synthesis of novel phenothiazine analogs with potential therapeutic applications.
• Quality Control (QC) & Assurance: Essential for in-house QC laboratories in pharmaceutical manufacturing to ensure the accuracy and reliability of impurity profiling and assay methods.

Basic Information

Product Name	7,8-Dihydroxychlorpromazine
CAS No.	21598-02-7
Molecular Formula	C17H19ClN2OS
Molecular Weight	334.86 g/mol
Synonyms	7,8-Dihydroxychlorpromazine; 2-Chloro-10-[3-(7,8-dihydroxy-10H-phenothiazin-10-yl)propyl]-10H-phenothiazine; Chlorpromazine-7,8-diol; 7,8-Dihydroxy-2-chloro-10-(3-dimethylaminopropyl)phenothiazine; 7,8-Dihydroxy CPZ; 7,8-DHCPZ
EINECS	Contact for details

Quality Control

Our 7,8-Dihydroxychlorpromazine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	Off-white to light brown powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.