Description

3,4,5,6-Tetrafluoropyridine-2-Carboxylic Acid is a highly fluorinated pyridine derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring a carboxylic acid group on a perfluorinated pyridine ring, makes it a versatile intermediate for introducing fluorine atoms into complex molecules, thereby modifying their physical, chemical, and biological properties. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing new active ingredients with enhanced metabolic stability, bioavailability, and lipophilicity.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for fluorinated drugs targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used to create advanced fluorinated herbicides, fungicides, and insecticides, where the fluorine atoms improve compound efficacy, environmental stability, and selectivity.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing specialized fluorinated ligands used in catalysis and material science.
• Fluorinated Liquid Crystal & Polymer Research: A valuable monomer for developing high-performance fluorinated polymers and liquid crystal materials with unique dielectric and surface properties.
• Chemical Research & Development: Employed in academic and industrial R&D for exploring new fluorination methodologies and creating libraries of fluorinated compounds for screening.

Basic Information

Product Name	3,4,5,6-Tetrafluoropyridine-2-Carboxylic Acid
CAS No.	21550-66-3
Molecular Formula	C6HF4NO2
Molecular Weight	195.07 g/mol
Synonyms	2-Pyridinecarboxylic acid, 3,4,5,6-tetrafluoro-; Tetrafluoropyridine-2-carboxylic acid; Perfluoropyridine-2-carboxylic acid; 2-Carboxy-3,4,5,6-tetrafluoropyridine; 3,4,5,6-Tetrafluoro-2-pyridinecarboxylic acid; 3,4,5,6-Tetrafluoropicolinic acid
EINECS	Contact for details

Quality Control

Our 3,4,5,6-Tetrafluoropyridine-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specified parameters. Our quality commitment supports applications requiring high-purity intermediates under cGMP or ISO 9001 guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.