Description

2-Chloro-5-(Fluorosulfonyl)Benzoic Acid is a versatile and highly functionalized benzoic acid derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both a reactive sulfonyl fluoride group and a carboxylic acid moiety, makes it an invaluable precursor for creating complex molecules with tailored properties. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and specialty intermediates.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring sulfonamide or sulfonate ester linkages.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, leveraging its reactive sites for structural diversification.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of specialty polymers, coatings, and advanced materials.
• Chemical Biology & Proteomics: The sulfonyl fluoride group is exploited in activity-based protein profiling (ABPP) and the development of covalent enzyme inhibitors.
• Ligand and Catalyst Development: Utilized for constructing complex chelating ligands and organocatalysts in asymmetric synthesis.
• Custom Synthesis and Contract Manufacturing: A high-value starting material for fine chemical manufacturers offering bespoke synthesis services.

Basic Information

Product Name	2-Chloro-5-(Fluorosulfonyl)Benzoic Acid
CAS No.	21346-66-7
Molecular Formula	C7H4ClFO4S
Molecular Weight	238.62 g/mol
Synonyms	5-(Fluorosulfonyl)-2-chlorobenzoic Acid; 2-Chloro-5-fluorosulfonylbenzoic Acid; Benzoic acid, 2-chloro-5-(fluorosulfonyl)-; 2-Chloro-5-fluorosulfonyl-benzoic acid; 2-Chloro-5-fluorosulfonylbenzoic acid; 2-Chloro-5-(fluorosulfonyl)benzoic acid; 2-Chloro-5-(fluorosulfonyl)benzoic acid (CAS 21346-66-7)
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-(Fluorosulfonyl)Benzoic Acid is manufactured under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via FT-IR and NMR, to ensure it meets the high standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.