Description

1-Methyl-L-Tryptophan is a modified amino acid derivative of L-tryptophan, featuring a methyl group at the 1-position of the indole ring. This structural modification makes it a valuable intermediate and research chemical for investigating biochemical pathways and developing novel compounds. It is primarily utilized in pharmaceutical research, academic laboratories, and fine chemical synthesis. The compound is offered with a focus on high purity and reliable supply to support critical R&D and manufacturing processes.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the research and synthesis of potential therapeutic agents, including enzyme inhibitors and receptor modulators.
• Biochemical Research: Used as a standard or probe in metabolic studies, particularly those involving tryptophan metabolism and the kynurenine pathway.
• Enzyme Inhibition Studies: Acts as a substrate analog for investigating the activity and mechanism of enzymes like indoleamine 2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO).
• Academic & Institutional Research: Employed in universities and research institutes for fundamental studies in medicinal chemistry and molecular biology.
• Reference Standard: Suitable for use as a certified reference material (CRM) in analytical method development and quality control laboratories.
• Fine Chemical Synthesis: A specialized precursor for synthesizing more complex molecules with potential applications in agrochemicals and material science.

Basic Information

Product Name	1-Methyl-L-Tryptophan
CAS No.	21339-55-9
Molecular Formula	C12H14N2O2
Molecular Weight	218.25 g/mol
Synonyms	1-Methyl-L-tryptophan; 1-Methyltryptophan; 1-MT; L-1-Methyltryptophan; (S)-2-Amino-3-(1-methyl-1H-indol-3-yl)propanoic acid; NSC 721782; Indoximod; α-Methyl-DL-tryptophan (related); DL-1-Methyltryptophan (racemic mixture)
EINECS	Contact for details

Quality Control

Our 1-Methyl-L-Tryptophan is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets stringent specifications. Certificates of Analysis (COA) documenting all test results are available upon request. We adhere to cGMP principles where applicable to support its use in regulated research environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Optical Rotation	[α]20/D: Specific range available on COA
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.