Description

γ-Amanitin is a highly potent, bicyclic octapeptide mycotoxin belonging to the amatoxin class, primarily isolated from the *Amanita* genus of mushrooms. This compound is of critical importance in biochemical and pharmacological research due to its specific and irreversible inhibition of RNA polymerase II, effectively halting mRNA synthesis. It is an essential tool for researchers in molecular biology, toxicology, and drug discovery who require a precise biochemical probe to study transcription mechanisms, evaluate hepatotoxicity, and develop potential antidotes.

Application

• Biochemical Research: Used as a highly specific inhibitor of RNA polymerase II to study eukaryotic transcription mechanisms and gene expression regulation.
• Toxicology Studies: Employed as a reference standard and active agent in research investigating the mechanisms of amatoxin poisoning, particularly hepatotoxicity.
• Drug Discovery & Development: Serves as a key tool compound in screening and evaluating potential antidotes or therapeutic agents for amatoxin poisoning.
• Diagnostic Development: Utilized in the development and calibration of analytical methods (e.g., HPLC-MS, ELISA) for the detection of amatoxins in biological and environmental samples.
• Cell Biology: Applied in studies of apoptosis and cell cycle arrest induced by transcription inhibition.
• Reference Standard: Provides a high-purity certified reference material (CRM) for quality control and analytical method validation in forensic and clinical laboratories.

Basic Information

Product Name	γ-Amanitin
CAS No.	21150-23-2
Molecular Formula	C39H54N10O14S
Molecular Weight	903.0 g/mol
Synonyms	γ-Amanitin; γ-Amanitine; Amanitin gamma; (3S,6R,14S,16R,21S,23S,28S,30S,33S,36S,39S)-39-[(1S)-1-Hydroxyethyl]-33-(4-hydroxyphenyl)methyl-21,23,28,30,36-pentahydroxy-3,6,14,16-tetramethyl-5,8,11,19,22,25,31,34,37-nonaoxo-1-oxa-4,7,10,18,21,24,32,35,38-nonaazatetracyclo[18.18.9.314,18.02,17]nonatriacontane-29-sulfonic acid; NSC 177321; Amatoxin; LLD-3 Amanitin
EINECS	Contact for details

Quality Control

Our γ-Amanitin is produced and handled under strict quality protocols to ensure the highest standards of purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant guidelines for research-grade biochemicals, ensuring reliable performance as a critical research tool.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum conforms to structure
Purity (HPLC)	≥ 95% (Area Percent)
Water Content (KF)	≤ 5.0 %
Solubility	Soluble in water, methanol, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.