Description

β-Amanitin is a highly potent cyclic peptide mycotoxin, a principal toxic component found in the deadly *Amanita* mushroom species. This compound is of critical importance in biochemical and pharmacological research due to its specific and irreversible inhibition of RNA polymerase II, a key enzyme in eukaryotic transcription. It is an essential reference standard and research tool for toxicologists, molecular biologists, and pharmaceutical scientists investigating transcription mechanisms, developing detection assays for food safety, and studying the pathophysiology of mushroom poisoning.

Application

• Biochemical Research: Used as a highly specific inhibitor of RNA polymerase II to study eukaryotic gene transcription, mRNA synthesis, and transcriptional regulation in cell-based and in vitro assays.
• Toxicology & Forensic Science: Serves as a critical analytical reference standard for the identification and quantification of amatoxins in biological samples (e.g., blood, urine, tissue) and environmental samples to diagnose poisoning.
• Pharmaceutical Development: Employed in mechanistic studies to explore novel therapeutic strategies that target transcription or to investigate apoptosis pathways induced by transcriptional arrest.
• Food & Environmental Safety: Acts as a calibration standard in advanced analytical methods (HPLC-MS/MS, ELISA) to monitor and control amatoxin contamination in wild mushrooms and agricultural products.
• Diagnostic Kit Manufacturing: Utilized in the development and quality control of immunoassay kits designed for the rapid detection of amatoxin poisoning.
• Academic Research: Fundamental tool for studying the structure-activity relationship of cyclic peptides, toxin metabolism, and the development of potential antidotes.

Basic Information

Product Name	β-Amanitin
CAS No.	21150-22-1
Molecular Formula	C39H54N10O14S
Molecular Weight	918.97 g/mol
Synonyms	β-Amanitin; β-Amanitin; Amanitin, β-; (3S,6S,9S,12R,15S,18S,21S,24R,30S,33S)-30-[(1R)-1-Hydroxyethyl]-33-(hydroxymethyl)-3,6,9,12,15,18,21,24-octaoxo-1,4,7,10,13,16,19,22,25,28,31-undecaazatricyclo[28.3.0.012,16]tritriacontane-29-sulfonic acid; NSC 177321; Amatoxin; Deadly amatoxin
EINECS	Contact for details

Quality Control

Our β-Amanitin is produced and handled under strict quality-controlled environments to ensure the highest standards of purity and consistency for research applications. Each batch is thoroughly characterized using advanced analytical techniques, including High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS). A comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and related substance analysis is provided with every shipment to guarantee traceability and reliability for your critical research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum conforms to reference
Purity (HPLC)	≥ 95%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 5.0%
Specific Optical Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.