Description

6'-o-Methyl α-Amanitin is a chemically modified derivative of the potent cyclic peptide toxin, α-amanitin. This compound is of significant interest in biochemical and pharmacological research, particularly as a highly selective inhibitor of RNA polymerase II. It is primarily utilized by research institutions, pharmaceutical developers, and diagnostic companies engaged in the study of transcription mechanisms, apoptosis, and the development of targeted therapies.

Application

• Biochemical Research: As a specific tool compound for inhibiting eukaryotic RNA polymerase II in mechanistic studies of transcription.
• Cancer Research: Investigation of its potential in antibody-drug conjugates (ADCs) for targeted cancer therapy due to its extreme potency.
• Apoptosis Studies: Used to induce programmed cell death in various cell lines to study downstream signaling pathways.
• Diagnostic Development: Serves as a key component in the development of immunoassays and test kits for the detection of amatoxin poisoning.
• Toxicology & Safety Testing: Employed as a reference standard in analytical methods to identify and quantify amatoxins in forensic and environmental samples.
• Neuroscience Research: Exploration of its effects on neuronal cells and its role in studying neurodegenerative processes.

Basic Information

Product Name	6'-o-Methyl α-Amanitin
CAS No.	21150-19-6
Molecular Formula	C40H54N10O13S
Molecular Weight	915.0 g/mol
Synonyms	6'-O-Methyl-α-amanitin; O6'-Methyl-α-amanitin; 6'-O-Methyl-α-amanitin; Methyl-α-amanitin; 6'-O-Methylamanin; α-Amanitin 6'-methyl ether; NSC 407303; Amanitin, 6'-O-methyl-α-
EINECS	Contact for details

Quality Control

Every batch of 6'-o-Methyl α-Amanitin is produced and analyzed under strict quality management protocols. We ensure high purity and consistency suitable for critical research applications. Comprehensive testing includes identity confirmation by spectroscopic methods and purity determination by HPLC. A Certificate of Analysis (COA) detailing batch-specific results is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in methanol, DMSO; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.