Description

n-Desisopropylpropranolol CAS NO 20862-11-7 is a key pharmaceutical intermediate and metabolite of the β-blocker propranolol. This compound is of significant value for research and development in pharmacology and analytical chemistry, serving as a critical reference standard. It is primarily needed by pharmaceutical manufacturers, contract research organizations (CROs), and analytical laboratories engaged in drug metabolism studies, impurity profiling, and quality control of propranolol-based products.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the identification and quantification of propranolol and its related substances in drug products and active pharmaceutical ingredients (APIs).
• Metabolite Research: Essential for in-vitro and in-vivo studies investigating the metabolic pathways, pharmacokinetics, and pharmacodynamics of propranolol.
• Impurity Synthesis and Control: Serves as a starting material or intermediate for synthesizing specified impurities and degradation products to support method validation and regulatory filings (e.g., ICH Q3A/B).
• Analytical Method Development: A critical component for developing and validating HPLC, LC-MS, and GC-MS methods for propranolol assay and impurity testing.
• Biochemical Research: Utilized in studies exploring β-adrenergic receptor interactions and the structure-activity relationships (SAR) of β-blocker analogs.

Basic Information

Product Name	n-Desisopropylpropranolol
CAS No.	20862-11-7
Molecular Formula	C13H19NO2
Molecular Weight	221.30 g/mol
Synonyms	1-(1-Naphthyloxy)-3-(propylamino)-2-propanol; Desisopropyl Propranolol; Propranolol Desisopropyl; Propranolol Impurity C; 1-[(1-Naphthalenyl)oxy]-3-(propylamino)-2-propanol; 3-(Propylamino)-1-(naphthalen-1-yloxy)propan-2-ol; N-Desisopropylpropranolol; UK-68862
EINECS	Contact for details

Quality Control

Our n-Desisopropylpropranolol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (IR, NMR, MS). We provide comprehensive Certificates of Analysis (COA) with batch-specific data, ensuring traceability and compliance with relevant standards for pharmaceutical intermediates and reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.