Description

2,5-Bis(Trifluoromethyl)Pyridine is a high-value fluorinated pyridine derivative, distinguished by its two trifluoromethyl groups which confer unique electronic and steric properties. This compound is a critical building block in advanced organic synthesis, prized for its ability to impart enhanced metabolic stability, lipophilicity, and bioavailability to target molecules. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, as well as by manufacturers of specialty materials and ligands for catalysis.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in antiviral, anticancer, and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the trifluoromethyl group enhances biological activity and environmental persistence.
• Ligand & Catalyst Development: Serves as a precursor for creating sophisticated nitrogen-containing ligands used in transition metal catalysis for fine chemical synthesis.
• Material Science: Employed in the synthesis of fluorinated polymers, liquid crystals, and electronic materials that require specific dielectric properties and chemical resistance.
• Chemical Research: A versatile reagent in academic and industrial R&D for exploring novel fluorination chemistry and structure-activity relationships (SAR).

Basic Information

Product Name	2,5-Bis(Trifluoromethyl)Pyridine
CAS No.	20857-44-7
Molecular Formula	C7H3F6N
Molecular Weight	215.10 g/mol
Synonyms	2,5-Bis(trifluoromethyl)pyridine; Pyridine, 2,5-bis(trifluoromethyl)-; α,α,α,α',α',α'-Hexafluoro-2,5-lutidine; 2,5-Di(trifluoromethyl)pyridine; 2,5-Bis(trifluoromethyl)azine; 2,5-BTFP; 20857-44-7 (CAS); 2,5-Bis(trifluoromethyl)pyridyl
EINECS	Contact for details

Quality Control

Every batch of 2,5-Bis(Trifluoromethyl)Pyridine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for sensitive synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by GC, HPLC, and NMR is supplied with each shipment. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its fluoride/strong alkali reactivity profile and high volatility, keep away from incompatible materials and ensure containers are properly sealed to prevent moisture ingress and evaporation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Purity (HPLC)	≥ 97.5%
Water Content (KF)	≤ 0.5%
Related Substances (GC/HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 2.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.