Description

N,n-Didemethylchlorpheniramine is a key pharmaceutical intermediate and reference standard of significant importance in research and development. This compound is primarily valued for its role in the synthesis and analytical characterization of antihistamine drugs and their metabolites. It is essential for pharmaceutical manufacturers, analytical laboratories, and research institutions focused on drug development, quality control, and metabolic studies. The substance is supplied to meet the stringent requirements of advanced chemical synthesis and high-purity analytical applications.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of advanced antihistamine active pharmaceutical ingredients (APIs) and related compounds.
• Analytical Reference Standard: Used as a high-purity standard in HPLC, GC-MS, and other chromatographic methods for quality control and method validation.
• Metabolite Studies: Serves as a reference compound in pharmacokinetic and drug metabolism research to identify and quantify metabolic pathways.
• Research & Development: Employed in medicinal chemistry for the design and development of new therapeutic agents targeting histamine receptors.
• Impurity Profiling: Utilized to identify, characterize, and control potential impurities and degradants in chlorpheniramine-based drug substances and products.

Basic Information

Product Name	N,n-Didemethylchlorpheniramine
CAS No.	20619-13-0
Molecular Formula	C16H19ClN2
Molecular Weight	274.79 g/mol
Synonyms	N,N-Didesmethylchlorpheniramine; 2-[4-Chlorophenyl(pyridin-2-yl)methoxy]-N,N-dimethylethanamine; Chlorpheniramine Impurity F; Chlorphenamine Impurity F; U-40456; 1-(4-Chlorophenyl)-1-(2-pyridinyl)-3-(dimethylamino)-2-propanol; Didemethylchlorpheniramine
EINECS	Contact for details

Quality Control

Our N,n-Didemethylchlorpheniramine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identity confirmation, purity assay, and impurity profiling via advanced techniques like HPLC and GC-MS. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with research and pharmaceutical intermediate standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.