Description

6A-Naltrexol is a key pharmaceutical intermediate and metabolite of naltrexone, a medication used in the management of alcohol and opioid dependence. Its precise chemical structure makes it critical for analytical research, method development, and the synthesis of related therapeutic compounds. This high-purity standard is essential for pharmaceutical R&D laboratories, forensic toxicology, and manufacturers of reference materials who require reliable and well-characterized substances for their work.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantitative and qualitative analysis of naltrexone and its metabolites in biological matrices.
• Metabolite Studies: Critical for pharmacokinetic and pharmacodynamic research to understand the metabolism, distribution, and elimination of naltrexone.
• Analytical Method Development: Serves as a primary standard for calibrating HPLC, LC-MS/MS, and GC-MS systems in clinical and forensic toxicology laboratories.
• Impurity Profiling: Employed in the identification and quantification of process-related impurities and degradation products in naltrexone API manufacturing.
• Biomedical Research: Utilized in vitro and in vivo studies to investigate the specific pharmacological activity of the 6A-Naltrexol metabolite.
• Forensic Analysis: A vital component in confirmatory testing protocols for compliance monitoring and medico-legal investigations.

Basic Information

Product Name	6A-Naltrexol
CAS No.	20410-98-4
Molecular Formula	C20H23NO4
Molecular Weight	341.40 g/mol
Synonyms	6α-Naltrexol; 6-α-Naltrexol; (5α)-17-(Cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-ol; 6α-Hydroxynaltrexone; Naltrexol; Noroxymorphone cyclopropylmethyl derivative
EINECS	Contact for details

Quality Control

Our 6A-Naltrexol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identity confirmation by IR and NMR, purity assessment by HPLC, and control of specific impurities. A detailed Certificate of Analysis (COA) providing batch-specific results is supplied with every order to ensure full traceability and compliance with your research or quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.