Description

Brefeldin A CAS NO 20350-15-6 is a potent, naturally occurring macrocyclic lactone metabolite with significant biological activity. This compound is a critical research tool for cell biologists, primarily valued for its ability to reversibly disrupt protein transport from the endoplasmic reticulum to the Golgi apparatus. It is essential for researchers in pharmaceutical development, biochemistry, and molecular biology studying intracellular trafficking, protein secretion, and vesicle formation mechanisms.

Application

• Cell Biology Research: A fundamental tool for studying intracellular protein transport, Golgi apparatus function, and endoplasmic reticulum (ER) stress.
• Cancer Research: Investigated for its potential to induce apoptosis and inhibit proliferation in various cancer cell lines.
• Virology Studies: Used to research viral assembly and egress pathways, particularly for enveloped viruses.
• Immunology Research: Employed to study cytokine secretion, antigen presentation, and immune cell function.
• Pharmaceutical Screening: Serves as a reference compound and positive control in high-throughput screening assays targeting secretory pathways.
• Plant Biology: Applied in studies of plant cell vesicular transport and response to fungal metabolites.

Basic Information

Product Name	Brefeldin A
CAS No.	20350-15-6
Molecular Formula	C16H24O4
Molecular Weight	280.36 g/mol
Synonyms	BFA; Cyanein; Decumbin; Ascotoxin; Brefeldin; (1R,2E,6S,10E,11aS,13S,14aR)-1,13-Dihydroxy-6-methyl-1,6,7,8,9,11a,13,14a-octahydro-4H-cyclopenta[f]oxacyclotetradecin-4,10(2H)-dione; 4,11a-Didehydro-1,13-dihydroxy-6-methyl-1,6,7,8,9,11a,13,14a-octahydro-4H-cyclopenta[f]oxacyclotetradecin-4,10(2H)-dione
EINECS	Contact for details

Quality Control

Our Brefeldin A is produced and tested under strict quality management protocols to ensure high purity and batch-to-batch consistency for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for research-grade biochemicals to support reliable and reproducible scientific results.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. For long-term storage, consider storage under an inert atmosphere. Allow the product to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder or crystals
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.