Description

Glycine-1-13C is a stable isotope-labeled analog of the fundamental amino acid glycine, where the carbon at the 1-position is enriched with the 13C isotope. This precise isotopic labeling is critical for advanced research and analytical applications, providing a non-radioactive tracer for metabolic and pharmacokinetic studies. It is an essential material for scientists and manufacturers in the pharmaceutical, biotechnology, and analytical chemistry sectors who require high-fidelity internal standards and probes for mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy.

Application

• Internal Standard for Mass Spectrometry (MS): Used as a quantitative reference standard in LC-MS and GC-MS analyses for accurate measurement of glycine and related metabolites in complex biological matrices.
• Metabolic Pathway Tracing: Serves as a stable isotopic tracer in 13C metabolic flux analysis to study central carbon metabolism, glycine cleavage system, and one-carbon metabolism in cell cultures, tissues, and whole organisms.
• NMR Spectroscopy: Provides a site-specific 13C NMR probe for structural elucidation, dynamics studies, and reaction monitoring in chemical and biochemical research.
• Pharmaceutical R&D: Employed in the development and validation of bioanalytical methods for drug candidates that interact with glycine pathways or require isotopic labeling.
• Diagnostic Reagent Manufacturing: Incorporated into high-precision in-vitro diagnostic (IVD) kits and assays for clinical research.
• Nutrient Studies: Applied in agricultural and nutritional science to track the assimilation and utilization of glycine in plants and animals.

Basic Information

Product Name	Glycine-1-13C
CAS No.	20110-59-2
Molecular Formula	C13CH5NO2
Molecular Weight	76.06 g/mol
Synonyms	1-13C-Glycine; [1-13C]Glycine; Glycine (1-13C); Aminoacetic-1-13C acid; 13C Labeled Glycine; Glycine-1-13C, 99 atom % 13C; NSC 7601-13C; Aminoethanoic-1-13C acid
EINECS	Contact for details

Quality Control

Our Glycine-1-13C is produced under stringent conditions to ensure exceptional isotopic and chemical purity, meeting the exacting requirements of analytical and research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic enrichment (atom % 13C), chemical purity by HPLC, and specific tests for identity and impurities. We adhere to cGMP principles where applicable, and specifications can be aligned with client-specific protocols for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 99 atom % 13C
Chemical Purity	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.