Description

4'-Deoxyvinblastine is a semi-synthetic vinca alkaloid derivative, a key intermediate in the synthesis of complex pharmaceutical compounds. This high-purity intermediate is critical for research and development in advanced oncology therapeutics, offering a reliable building block for novel drug discovery. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and fine chemical manufacturers focused on developing next-generation cancer treatments and studying microtubule dynamics.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of complex anti-cancer agents and novel vinca alkaloid derivatives.
• Biochemical Research: Used as a reference standard and active compound in studies investigating microtubule assembly inhibition and cell cycle arrest mechanisms.
• Oncology Drug Discovery: Serves as a key scaffold for the development and structure-activity relationship (SAR) studies of new chemotherapeutic candidates.
• Academic & Clinical Research: Employed in laboratory settings to study the pharmacological effects and metabolic pathways of vinca alkaloids.
• Fine Chemical Synthesis: Utilized in multi-step organic synthesis for producing specialized, high-value chemical entities in a controlled GMP or non-GMP environment.

Basic Information

Product Name	4'-Deoxyvinblastine
CAS No.	20072-25-7
Molecular Formula	C46H58N4O9
Molecular Weight	810.98 g/mol
Synonyms	4'-Deoxyvinblastine; Deoxyvinblastine; 3',4'-Didehydro-4'-deoxyvinblastine; 4'-Deoxyvincaleukoblastine; NSC 354646; LEU 29060; Vinblastine, 4'-deoxy-; (3α,4β,5α,12α,19α)-4-(Acetyloxy)-15-[(5S,7R,9S)-5-ethyl-5-hydroxy-9-(methoxycarbonyl)-1,4,5,6,7,8,9,10-octahydro-2H-3,7-methanoazacycloundecino[5,4-b]indol-9-yl]-3-hydroxy-16-methoxy-1-methyl-6,7-didehydroaspidospermidine-3-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our 4'-Deoxyvinblastine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by spectroscopic methods (IR, NMR), and residual solvent analysis. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific research or pharmaceutical intermediate requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to prevent degradation. For long-term storage, consider storing at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 1.0%
Assay (HPLC)	97.0% - 102.0% (on anhydrous basis)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.