Description

4-(Trifluoromethyl)Benzene-1-Sulfonyl Chloride is a versatile and highly reactive organosulfur compound, serving as a critical building block in advanced organic synthesis. Its core value lies in the trifluoromethyl and sulfonyl chloride functional groups, which enable the efficient introduction of the sulfonamide moiety into target molecules, a key step in developing compounds with enhanced biological activity and physicochemical properties. This intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the synthesis of active pharmaceutical ingredients (APIs), herbicides, and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of sulfonamide-based drugs, including enzyme inhibitors and receptor antagonists.
• Agrochemical Synthesis: Used in the production of novel herbicides and pesticides, where the trifluoromethyl group enhances lipophilicity and metabolic stability.
• Material Science: Employed in the creation of specialty polymers, liquid crystals, and advanced functional materials.
• Chemical Research & Development: A valuable reagent for medicinal chemistry and process chemistry for constructing complex molecular architectures.
• Dye and Pigment Manufacturing: Acts as an intermediate in the synthesis of specialized dyes and colorants.

Basic Information

Product Name	4-(Trifluoromethyl)Benzene-1-Sulfonyl Chloride
CAS No.	2991-42-6
Molecular Formula	C7H4ClF3O2S
Molecular Weight	244.62 g/mol
Synonyms	p-(Trifluoromethyl)benzenesulfonyl chloride; α,α,α-Trifluoro-p-toluenesulfonyl chloride; 4-(Trifluoromethyl)benzenesulfonyl chloride; 4-Trifluoromethylphenylsulfonyl chloride; p-Trifluoromethylphenylsulfonyl chloride; PTSC; Tosyl chloride, p-trifluoromethyl-
EINECS	221-060-8

Quality Control

Our production of 4-(Trifluoromethyl)Benzene-1-Sulfonyl Chloride adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including HPLC, GC, and NMR to verify identity and quantify impurities. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment. We operate in compliance with cGMP principles where applicable, ensuring our product meets the exacting standards required for pharmaceutical and fine chemical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis. Keep away from strong bases, oxidizing agents, and sources of ignition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.