Description

2,4-Dichloro-5-Fluoropyrimidine is a versatile and high-value halogenated pyrimidine building block essential for advanced organic synthesis. Its molecular structure, featuring reactive chlorine and fluorine atoms at specific positions, makes it a critical intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for developing active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of antiviral, anticancer, and other biologically active compounds, particularly in nucleoside and nucleotide chemistry.
• Agrochemical Synthesis: Used to create advanced herbicides, fungicides, and insecticides where the fluoropyrimidine core contributes to efficacy and selectivity.
• Material Science Research: Serves as a building block for developing specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Research & Development: Employed in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs producing bespoke compounds for client projects.

Basic Information

Product Name	2,4-Dichloro-5-Fluoropyrimidine
CAS No.	2927-71-1
Molecular Formula	C4HCl2FN2
Molecular Weight	166.96 g/mol
Synonyms	5-Fluoro-2,4-dichloropyrimidine; 2,4-Dichloro-5-fluoropyrimidine; 5-Fluoropyrimidine-2,4-dichloride; 2,4-Dichloro-5-fluoro-1,3-diazine; Fluoropyrimidine dichloride; NSC 523764; AI3-52290
EINECS	220-888-7

Quality Control

Our 2,4-Dichloro-5-Fluoropyrimidine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring high-purity intermediates for GMP and non-GMP synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	48 - 52 °C
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.