Description

Benzamil Hydrochloride is a potent and selective inhibitor of the epithelial sodium channel (ENaC). This high-purity compound is critical for advanced research in renal physiology, hypertension, and pulmonary function. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and contract research organizations (CROs) for mechanistic studies and drug discovery programs.

Application

• Pharmacological Research: Used as a key research tool to study the role of ENaC in sodium and water balance, blood pressure regulation, and related disorders.
• Respiratory Physiology Studies: Applied in investigations of airway surface liquid regulation and cystic fibrosis research.
• Cardiovascular Research: Employed in preclinical models to explore the mechanisms of hypertension and heart failure.
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development and validation in quality control laboratories.
• Biochemical Assay Development: Used in high-throughput screening (HTS) assays to identify novel modulators of sodium transport.
• Academic Teaching & Advanced Studies: A standard compound for graduate-level studies in pharmacology and molecular biology.

Basic Information

Product Name	Benzamil Hydrochloride
CAS No.	2898-76-2
Molecular Formula	C12H13ClN4O · HCl
Molecular Weight	309.17 g/mol
Synonyms	Benzamil HCl; N-Benzyl-3,5-diamino-6-chloropyrazine-2-carboxamide hydrochloride; 3,5-Diamino-N-benzyl-6-chloropyrazinecarboxamide monohydrochloride; 6-Chloro-3,5-diamino-N-(phenylmethyl)pyrazine-2-carboxamide hydrochloride; ENaC Inhibitor Benzamil Hydrochloride; Benzamil HCL; Benzamil Hydrochloride (Benzamil HCl)
EINECS	220-812-8

Quality Control

Our Benzamil Hydrochloride is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and residual solvent analysis. A comprehensive Certificate of Analysis (COA) detailing all test results and specifications is provided with every shipment to ensure traceability and compliance with your research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.