Description

3-Chlorobenzenesulfonyl Chloride is a versatile and highly reactive organosulfur compound, serving as a critical building block in advanced organic synthesis. Its primary value lies in its dual functionality as both an electrophilic sulfonylating agent and a precursor for sulfonamide derivatives, enabling the construction of complex molecular architectures. This intermediate is essential for research and production chemists in the pharmaceutical, agrochemical, and specialty chemical industries, where it is used to develop active ingredients, functional materials, and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of sulfonamide-based drugs, including diuretics, anticonvulsants, and protease inhibitors.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and plant growth regulators that contain sulfonylurea or sulfonamide moieties.
• Dyestuff and Pigment Manufacturing: Acts as a sulfonating agent to introduce sulfonyl chloride groups into aromatic systems, creating water-soluble dyes and colorants.
• Polymer Modification: Employed to functionalize polymers and resins, imparting specific properties like improved solubility, adhesion, or reactivity.
• Chemical Research & Development: A valuable reagent in medicinal chemistry and material science for creating novel sulfonamide libraries and exploring structure-activity relationships.
• Ligand and Catalyst Preparation: Useful for synthesizing specialized ligands and catalysts used in asymmetric synthesis and transition metal catalysis.

Basic Information

Product Name	3-Chlorobenzenesulfonyl Chloride
CAS No.	2888-06-4
Molecular Formula	C6H4Cl2O2S
Molecular Weight	211.06 g/mol
Synonyms	m-Chlorobenzenesulfonyl Chloride; 3-Chlorophenylsulfonyl Chloride; Benzenesulfonyl chloride, 3-chloro-; m-Chlorophenylsulfonyl Chloride; 1-Chloro-3-(chlorosulfonyl)benzene; 3-Chlorobenzene-1-sulfonyl Chloride; Meta-Chlorobenzenesulfonyl Chloride
EINECS	220-764-5

Quality Control

Our 3-Chlorobenzenesulfonyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing assay, impurity profiles, and physical characteristics. Our production adheres to cGMP principles where applicable, ensuring reliability for critical applications in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen) after opening to prevent hydrolysis. Keep away from strong bases, oxidizing agents, and sources of ignition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or lumps
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	40 - 44 °C
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.