Description

4,6-Difluoropyrimidine is a versatile fluorinated heterocyclic building block essential for advanced organic synthesis. This compound is highly valued for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where its difluoropyrimidine core enables precise molecular modifications. It is primarily sought after by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for constructing complex molecules with targeted biological activity.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly kinase inhibitors and antiviral agents.
• Agrochemical Synthesis: Used in the development of modern herbicides, fungicides, and insecticides with improved efficacy and selectivity.
• Material Science: Serves as a building block for creating advanced polymers and liquid crystals with specific electronic or optical properties.
• Chemical Research: Employed in academic and industrial R&D for exploring new reactions and creating libraries of fluorinated compounds.
• Fluorine Chemistry: Acts as a versatile substrate for further functionalization via nucleophilic aromatic substitution (SNAr) reactions.

Basic Information

Product Name	4,6-Difluoropyrimidine
CAS No.	2802-62-2
Molecular Formula	C4H2F2N2
Molecular Weight	116.07 g/mol
Synonyms	4,6-Difluoropyrimidine; Pyrimidine, 4,6-difluoro-; 4,6-Difluoro-1,3-diazine; 4,6-Difluoro-pyrimidine; 2802-62-2; NSC 404087; AI3-52731; CCRIS 9356; EINECS 220-548-1; 4,6-Difluoro-1,3-diazabenzene
EINECS	220-548-1

Quality Control

Our 4,6-Difluoropyrimidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We support cGMP standards for pharmaceutical applications and can provide documentation for regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.