Description

5-Chlorothiophene-2-Sulfonyl Chloride is a versatile and highly reactive organosulfur compound, primarily serving as a key sulfonylation reagent and a critical building block in advanced organic synthesis. Its value lies in its ability to introduce the 5-chlorothiophene-2-sulfonyl moiety, a functional group of significant interest in the development of active pharmaceutical ingredients and specialty chemicals. This intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries who require high-purity, reliable building blocks for complex molecule construction.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting various therapeutic areas.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging the thiophene scaffold for bioactivity.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of conductive polymers, organic semiconductors, and advanced polymeric materials.
• Dye and Pigment Manufacturing: Acts as an intermediate in the production of specialized dyes and pigments that incorporate sulfur heterocycles.
• Ligand and Catalyst Development: Utilized for synthesizing complex ligands for metal catalysis and organocatalysts.
• Custom Chemical Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for bespoke synthesis projects and library production for high-throughput screening.

Basic Information

Product Name	5-Chlorothiophene-2-Sulfonyl Chloride
CAS No.	2766-74-7
Molecular Formula	C4H2Cl2O2S2
Molecular Weight	217.09 g/mol
Synonyms	2-Chlorosulfonyl-5-chlorothiophene; 5-Chloro-2-thiophenesulfonyl chloride; 5-Chloro-2-thienylsulfonyl chloride; 5-Chlorothiophene-2-sulfochloride; 2-Thiophenesulfonyl chloride, 5-chloro-; Thiophene-2-sulfonyl chloride, 5-chloro-; 5-Chloro-2-thiophenesulfonyl chloride; 5-Chlorothiophene-2-sulfonic acid chloride
EINECS	220-440-3

Quality Control

Our 5-Chlorothiophene-2-Sulfonyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature and reactivity as a strong acid/organic solvent derivative, it should be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity. Recommended storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.