Description

Piericidin A is a potent, naturally occurring mitochondrial complex I inhibitor, widely recognized for its role in biochemical and pharmacological research. This compound is crucial for studying cellular respiration, oxidative stress, and neurodegenerative disease models, providing a key tool for understanding metabolic pathways. It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies engaged in metabolic and aging-related studies.

Application

• Biochemical Research: As a specific inhibitor of NADH:ubiquinone oxidoreductase (Complex I) for studying mitochondrial electron transport chain function and bioenergetics.
• Pharmacological Studies: Used to induce cellular models of mitochondrial dysfunction, oxidative stress, and apoptosis for drug discovery and toxicology screening.
• Neurodegenerative Disease Research: Employed to create *in vitro* and *in vivo* models relevant to Parkinson's disease and other disorders linked to mitochondrial impairment.
• Insecticide & Acaricide Research: Investigated for its natural pesticidal properties as a lead compound for developing novel agrochemicals.
• Aging & Metabolic Studies: Applied in research exploring the role of mitochondrial activity in the aging process and metabolic syndromes.

Basic Information

Product Name	Piericidin A
CAS No.	2738-64-9
Molecular Formula	C₂₅H₃₇NO₄
Molecular Weight	415.57 g/mol
Synonyms	Antimycin A3; Piericidin A1; Antibiotic PA 86; NSC 163042; 2,4-Pyridinediol, 3-[(1E,3E,5E,7E)-8-[(2R,5R)-5-ethenyl-2,5-dihydro-5-methyl-2-furanyl]-3,7-dimethyl-1,3,5,7-octatetraen-1-yl]-; (2R,5R)-5-Ethenyl-2,5-dihydro-2-[(2E,4E,6E,8E)-3-methyl-9-(4-pyridinyl)-2,4,6,8-nonatetraen-1-ylidene]-3-furanone
EINECS	Contact for details

Quality Control

Our Piericidin A is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot is characterized using advanced analytical techniques, including HPLC, NMR, and MS, to confirm identity and potency. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to support your research integrity and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. Due to its hygroscopic (moisture-sensitive) nature, the container should be allowed to reach room temperature before opening to minimize condensation and exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	Yellow to light brown powder or crystalline solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay	≥ 98%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Solubility	Soluble in DMSO, ethanol, methanol; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.