Description

6-Chloro-9H-Purine-2-Sulfonyl Fluoride is a high-value, multi-functional chemical building block that serves as a key intermediate in advanced organic synthesis. Its unique structure, combining a purine core with a reactive sulfonyl fluoride group, makes it indispensable for creating novel compounds with targeted biological activity. This product is primarily utilized by research and development teams in the pharmaceutical and agrochemical industries for drug discovery and the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel purine-based therapeutics, including kinase inhibitors, antiviral agents, and anticancer compounds.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and plant growth regulators that leverage the purine scaffold for biological activity.
• Chemical Biology & Proteomics: The sulfonyl fluoride moiety acts as a reactive handle for covalent modification of proteins, useful in activity-based protein profiling (ABPP) and the development of covalent inhibitors.
• Material Science: Serves as a specialty monomer or cross-linking agent in the development of advanced polymers and functional materials.
• Academic & Contract Research: A valuable reagent for synthetic chemistry research in universities and CROs (Contract Research Organizations) exploring new heterocyclic chemistry and sulfur(VI) fluoride exchange (SuFEx) click chemistry.

Basic Information

Item	Details
Product Name	6-Chloro-9H-Purine-2-Sulfonyl Fluoride
CAS No.	2706-92-5
Molecular Formula	C5H2ClFN4O2S
Molecular Weight	236.61 g/mol
Synonyms	6-Chloro-2-sulfonylfluoride-9H-purine; 6-Chloropurine-2-sulfonyl Fluoride; 2-Sulfonyl Fluoride-6-chloropurine; 6-Chloro-9H-purine-2-sulfonyl fluoride; 6-Chloro-2-(fluorosulfonyl)-9H-purine; 6-Chloro-2-fluorosulfonylpurine; Purine, 6-chloro-2-(fluorosulfonyl)-; 2706-92-5 (CAS)
EINECS	Contact for details

Quality Control

Every batch of 6-Chloro-9H-Purine-2-Sulfonyl Fluoride is manufactured under strict quality management protocols. We employ advanced analytical techniques, including HPLC, NMR, and MS, to ensure identity, purity, and consistency meet the exacting standards required for research and process development. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment to guarantee full traceability and compliance with your internal quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.