Description

7,12-Dimethylbenz(A)Anthracene-Dihydrodiol is a high-purity, synthetically derived dihydrodiol derivative of the polycyclic aromatic hydrocarbon (PAH) 7,12-dimethylbenz[a]anthracene (DMBA). This compound is of significant value as a crucial biochemical research standard and metabolic intermediate for investigating carcinogenic mechanisms. It is primarily utilized by pharmaceutical R&D laboratories, toxicology research institutions, and academic facilities focused on cancer biology, metabolic pathway analysis, and chemical safety assessment.

Application

• Biochemical Research Standard: Serves as a critical reference standard and metabolic intermediate in studies of PAH activation and carcinogenesis.
• Toxicology & Carcinogenicity Studies: Used in in vitro and in vivo models to investigate the metabolic pathways and DNA adduct formation of DMBA.
• Enzymology Research: Employed as a substrate for studying the activity of cytochrome P450 enzymes and epoxide hydrolases involved in xenobiotic metabolism.
• Pharmaceutical Development: Utilized in early-stage research for screening potential chemopreventive agents or inhibitors of metabolic activation.
• Academic & Institutional Research: A key reagent for universities and research institutes conducting fundamental research in chemical biology and environmental health sciences.

Basic Information

Item	Detail
Product Name	7,12-Dimethylbenz(A)Anthracene-Dihydrodiol
CAS No.	2518-00-5
Molecular Formula	C20H18O2
Molecular Weight	290.36 g/mol
Synonyms	DMBA-dihydrodiol; 7,12-DMBA-dihydrodiol; 7,12-Dimethylbenz[a]anthracene-3,4-dihydrodiol; 3,4-Dihydroxy-3,4-dihydro-7,12-dimethylbenz[a]anthracene; trans-3,4-Dihydroxy-3,4-dihydro-7,12-dimethylbenz[a]anthracene; (±)-7,12-Dimethylbenz[a]anthracene-3,4-diol; Benz[a]anthracene-3,4-diol, 7,12-dimethyl-
EINECS	Contact for details

Quality Control

Our 7,12-Dimethylbenz(A)Anthracene-Dihydrodiol is manufactured under strict quality protocols to ensure batch-to-batch consistency and high purity, essential for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including HPLC purity analysis and structural confirmation (NMR, MS). A detailed Certificate of Analysis (COA) documenting identity, purity, and related substances is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Individual impurity ≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.