Description

4-Aminobenzamidine Dihydrochloride is a high-purity, potent, and selective serine protease inhibitor essential for biochemical research and pharmaceutical development. Its core value lies in its ability to specifically inhibit enzymes like trypsin, thrombin, and plasmin, making it a critical tool for studying proteolytic pathways and developing therapeutic agents. This compound is primarily needed by research institutions, diagnostic kit manufacturers, and pharmaceutical companies engaged in cardiovascular, inflammatory, and oncology research.

Application

• Biochemical Research: As a selective inhibitor for trypsin, thrombin, and other serine proteases in enzymatic studies and mechanism of action research.
• Pharmaceutical Development: Serves as a key intermediate or active pharmacophore in the synthesis of novel protease inhibitor drugs targeting thrombosis, inflammation, and cancer.
• Diagnostic Reagents: Used in the formulation of diagnostic kits and assays for clinical testing, particularly those measuring blood coagulation factors and other protease activities.
• Cell Culture & Proteomics: Employed to prevent unwanted proteolytic degradation during cell lysis and protein extraction procedures, ensuring sample integrity.
• Academic Research: A fundamental reagent in university and institutional labs for graduate-level studies in enzymology, biochemistry, and molecular biology.

Basic Information

Product Name	4-Aminobenzamidine Dihydrochloride
CAS No.	2498-50-2
Molecular Formula	C7H11N3 • 2HCl
Molecular Weight	230.10 g/mol
Synonyms	p-Aminobenzamidine Dihydrochloride; Benzamidine, 4-amino-, dihydrochloride; 4-Aminobenzamidine • 2HCl; (4-Aminophenyl)methanimidamide dihydrochloride; APBA • 2HCl; Protease Inhibitor 2488-50-2; Trypsin Inhibitor (4-Aminobenzamidine based)
EINECS	219-690-6

Quality Control

Our 4-Aminobenzamidine Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and heavy metal screening. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all test results against stringent in-house specifications. Our quality commitment ensures batch-to-batch consistency for your critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. The product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment. For long-term storage, consider storing under an inert atmosphere to ensure maximum stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm
Solubility	Clear, colorless solution in water (50 mg/mL)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.