Description

(Phe2,Orn8)-Oxytocin CAS NO 2480-41-3 is a synthetic analogue of the neurohypophysial hormone oxytocin, featuring specific amino acid substitutions at positions 2 and 8. This modification is designed to enhance receptor selectivity, stability, or biological activity for advanced research applications. It is a critical tool for researchers in neuroendocrinology, pharmacology, and drug discovery, particularly those investigating peptide hormone signaling, receptor-ligand interactions, and the development of novel therapeutic agents.

Application

• Biomedical Research: Fundamental studies on oxytocin receptor (OXTR) binding affinity, selectivity, and downstream signaling pathways.
• Pharmacological Profiling: Evaluation of modified peptide analogues for enhanced metabolic stability, bioavailability, or altered agonist/antagonist properties.
• Drug Discovery & Development: Serving as a lead compound or reference standard in the design of new therapeutics targeting social behavior, stress, lactation, or uterine contraction.
• Neuroscience Studies: Investigating the role of specific peptide sequences in neuroendocrine functions, social cognition, and behavioral modulation in model systems.
• Biochemical Assay Development: Use as a calibrated standard in receptor binding assays (RBA), enzyme-linked immunosorbent assays (ELISA), or other in vitro test systems.
• Academic & Institutional Research: Supporting cutting-edge studies in university and government laboratories focused on peptide chemistry and neurobiology.

Basic Information

Product Name	(Phe2,Orn8)-Oxytocin
CAS No.	2480-41-3
Molecular Formula	C₄₆H₆₆N₁₂O₁₂S₂
Molecular Weight	1043.2 g/mol
Synonyms	[Phe², Orn⁸]-Oxytocin; 1-{[(4R,7S,10S,13S,16S,19R)-19-Amino-13-(2-amino-2-oxoethyl)-7-(2-amino-3-phenylpropanoyl)-10-(4-hydroxybenzyl)-16-[(4-aminobutyl)carbamoyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl]carbonyl}-L-prolyl-L-leucylglycinamide; Oxytocin, 2-phenylalanine-8-ornithine-; Orn⁸-oxytocin; Phe²-Oxytocin analogue
EINECS	Contact for details

Quality Control

Every batch of (Phe2,Orn8)-Oxytocin is manufactured and analyzed under strict quality management protocols. We provide comprehensive analytical data to support your research, ensuring identity, purity, and consistency. Certificates of Analysis (COA) detailing purity (by HPLC), peptide content, and related substance profiles are available for all material supplied.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, desiccate and keep frozen. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0%
Single Impurity (HPLC)	≤ 2.0%
Water Content (KF)	≤ 8.0%
Acetate Content (HPLC)	≤ 12.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.