Description

Dnqx (CAS NO 2379-57-9) is a potent and selective competitive antagonist for the AMPA/kainate subtype of ionotropic glutamate receptors. This compound is a critical research tool for neuropharmacological studies, enabling the precise investigation of excitatory synaptic transmission and neuronal excitability. It is essential for researchers and pharmaceutical developers in neuroscience, pharmacology, and drug discovery targeting neurological disorders.

Application

• Neuroscience Research: Used as a selective AMPA/kainate receptor antagonist to study excitatory neurotransmission, synaptic plasticity, and long-term potentiation (LTP).
• Pharmacological Studies: A key tool compound for in vitro and ex vivo experiments to elucidate the role of glutamate receptors in neuronal signaling pathways.
• Neuroprotection Research: Investigated in models of neuronal excitotoxicity, stroke, epilepsy, and neurodegenerative diseases to understand receptor-mediated cell death mechanisms.
• Drug Discovery & Development: Serves as a reference standard and pharmacological probe for screening and developing novel therapeutics targeting glutamate receptors.
• Cellular & Molecular Biology: Employed to isolate and characterize receptor subtypes and their functions in various cell culture and tissue preparations.
• Behavioral Studies: Used in animal models to study the effects of AMPA/kainate receptor blockade on learning, memory, and other cognitive functions.

Basic Information

Product Name	Dnqx
CAS No.	2379-57-9
Molecular Formula	C12H6N4O4
Molecular Weight	270.20 g/mol
Synonyms	6,7-Dinitroquinoxaline-2,3-dione; DNQX; FG 9041; 6,7-Dinitro-2,3-quinoxalinedione; 6,7-Dinitro-1,4-dihydro-2,3-quinoxalinedione; AMPA/Kainate Receptor Antagonist; FG-9041
EINECS	Contact for details

Quality Control

Our Dnqx is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for research-grade chemicals, ensuring reliable performance in your experimental systems.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; ensure the container is sealed tightly after each use to minimize exposure to atmospheric moisture and light.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Solubility	Soluble in DMSO, slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.