Description

1-Chloro-2,5-Difluorobenzene is a versatile halogenated aromatic building block of significant importance in advanced organic synthesis. This compound matters for its role as a key intermediate in the production of complex molecules, particularly in the pharmaceutical and agrochemical sectors. Industries that need it include manufacturers of active pharmaceutical ingredients (APIs), liquid crystal materials, and specialty agrochemicals.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of various active pharmaceutical ingredients (APIs), especially those containing difluorophenyl motifs.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and insecticides where the chloro-difluoro substitution pattern confers specific biological activity.
• Liquid Crystal Materials: Serves as a building block for fluorinated liquid crystal compounds used in display technologies.
• Organic Electronics: Employed in the synthesis of fluorinated organic semiconductors and charge-transport materials.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create complex biaryl structures.
• Functional Material Research: Used in R&D for developing novel polymers, ligands, and catalysts with tailored properties.

Basic Information

Product Name	1-Chloro-2,5-Difluorobenzene
CAS No.	2367-91-1
Molecular Formula	C6H3ClF2
Molecular Weight	148.54 g/mol
Synonyms	2,5-Difluorochlorobenzene; 2-Chloro-1,4-Difluorobenzene; 1-Chloro-2,5-Difluorobenzol; Benzene, 1-chloro-2,5-difluoro-; 2,5-Difluoro-1-chlorobenzene; 2,5-Difluorophenyl chloride
EINECS	219-124-9

Quality Control

Our 1-Chloro-2,5-Difluorobenzene is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure it meets the high-purity standards required for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and bases. Recommended storage temperature is between 15°C and 25°C. Keep container tightly sealed when not in use to prevent moisture absorption and volatilization.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%
Related Substances (GC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%
Density (at 20°C)	~1.40 g/mL
Refractive Index (n20D)	~1.48

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.