Description

(-)-2-Amino-6-[(1S,2R)-1,2,3-Trihydroxypropyl]Pteridine-4(1H)-One is a high-purity, stereochemically defined pteridine derivative. This compound is of significant interest as a key chiral intermediate and reference standard in advanced pharmaceutical research and development. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical sectors for the synthesis of novel therapeutic agents and biochemical studies.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral building block for the synthesis of complex drug molecules, particularly in areas targeting metabolic and neurological pathways.
• Biochemical Research: Used as a reference standard and precursor in enzymatic studies and metabolic pathway analysis due to its structural similarity to biologically active pterins.
• Process Chemistry: Employed in the development and scale-up of synthetic routes for active pharmaceutical ingredients (APIs) requiring high stereochemical purity.
• Analytical Standard: Acts as a high-purity calibration standard for HPLC, LC-MS, and other analytical methods in quality control and research laboratories.
• Fine Chemical Synthesis: Utilized in the preparation of specialized ligands, catalysts, and other sophisticated organic molecules for research applications.

Basic Information

Product Name	(-)-2-Amino-6-[(1S,2R)-1,2,3-Trihydroxypropyl]Pteridine-4(1H)-One
CAS No.	2277-43-2
Molecular Formula	C9H11N5O4
Molecular Weight	253.22 g/mol
Synonyms	L-Biopterin; (6R)-L-erythro-Biopterin; 2-Amino-6-[(1S,2R)-1,2,3-trihydroxypropyl]-4(1H)-pteridinone; 6-(L-erythro-1,2-Dihydroxypropyl)-2-amino-4-hydroxypteridine; (-)-Biopterin; Vitamin BH4 (cofactor form); (6R)-5,6,7,8-Tetrahydrobiopterin precursor; L-erythro-Biopterin
EINECS	218-902-5

Quality Control

Our (-)-2-Amino-6-[(1S,2R)-1,2,3-Trihydroxypropyl]Pteridine-4(1H)-One is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets stringent specifications for research and development use. A Certificate of Analysis (COA) detailing identity, purity, and chiral excess is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere conditions.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (6R isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.