Description

2,5-Difluoroiodobenzene is a high-value halogenated aromatic building block essential for advanced organic synthesis. Its unique structure, featuring both fluorine and iodine substituents, makes it a versatile intermediate for creating complex molecules with tailored properties. This compound is primarily utilized by researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries for applications such as cross-coupling reactions and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for fluorinated drug candidates targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and pesticides, where the fluorine atoms enhance biological activity and environmental stability.
• Material Science: Serves as a building block for creating specialty polymers, liquid crystals, and organic electronic materials due to its ability to modify electronic properties.
• Cross-Coupling Reactions: The iodine moiety acts as an excellent handle for palladium-catalyzed reactions like Suzuki, Sonogashira, and Heck couplings to form biaryl systems.
• Ligand and Catalyst Development: Employed in the preparation of sophisticated ligands for catalysis and molecular recognition studies.
• Fluorine Chemistry Research: A valuable reagent for studying structure-activity relationships (SAR) and introducing fluorine into complex molecular architectures.

Basic Information

Item	Detail
Product Name	2,5-Difluoroiodobenzene
CAS No.	2265-92-1
Molecular Formula	C6H3F2I
Molecular Weight	239.99 g/mol
Synonyms	1,4-Difluoro-2-iodobenzene; 2-Iodo-1,4-difluorobenzene; Benzene, 1,4-difluoro-2-iodo-; 2,5-Difluorophenyl iodide; 2,5-Difluoro-1-iodobenzene; 2,5-Difluorobenzene, iodo-
EINECS	Contact for details

Quality Control

Our 2,5-Difluoroiodobenzene is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as assay, identity, and impurity profiles. We adhere to relevant industry standards and can provide material suitable for research and development under cGMP guidelines as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider storing under an inert atmosphere to maximize shelf life.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.